Pharmacological activity of salvinorin A, the major component of Salvia divinorum.

Salvinorin A, the active compound in the hallucinogenic plant Salvia divinorum (magic mint), produces hallucinogenic, antinociceptive (pain-relieving), and antidepressant-like behavioral effects in animals. The compound also shows addictive properties. Its mechanisms of action remain unclear or not well recognized. The paper reviews these behavioral effects and the legal status of the plant and its derivatives. Given the rising recreational use of Salvia divinorum, compiling pharmacological data on salvinorin A is important.

Study at a glance

Abstract

The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been historically used for divination and shamanism by the Mazatecs. Today, S. divinorum has become increasingly popular as a recreational drug for its hallucinogenic effects. The non-nitrogenous diterpene, salvinorin A, the major active component of S. divinorum, is responsible for the hallucinogenic effect of this plant. Here, we described the behavioral effects of salvinorin A in animals including the addictive, antinociception and antidepressant properties of the drug. The present paper also demonstrates the not well recognized (or unclear) mechanisms of action of salvinorin A. The last part of the paper presents information about the legal status of S. divinorum and its derivatives. Taking into account the increasing popularity and consumption of salvinorin A and S. divinorum today, it is important to collect all data on the pharmacological profile of this plant and its products.