Ibogaine interferes with motivational and somatic effects of naloxone-precipitated withdrawal from acutely administered morphine.
Linda A Parke, Page Burton, Robert V Mcdonald, Joseph A Kim, Shepard Siegel
Progress in neuro-psychopharmacology & biological psychiatry February 1, 2002 DOI: 10.1016/s0278-5846(01)00268-8 via PubMed
Summary
AI-generated from the abstractIbogaine reduces both the physical signs and the motivational distress of opioid withdrawal in rats. In two experiments, rats given morphine only twice and then injected with naloxone to trigger withdrawal showed less aversion to a place associated with withdrawal and fewer physical withdrawal reactions when they had received ibogaine four hours earlier, compared with rats given saline. The results suggest ibogaine can interfere with withdrawal even after limited opioid exposure, targeting not just somatic symptoms but also the motivational aspects that make withdrawal distressing.
Study at a glance
| Characteristics | Controlled experiment Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Ibogaine |
| Topics | Addiction Ibogaine |
| Keywords | Compound Acute opioid withdrawal Physical symptoms Motivational aspects |
| Citations | 17 |
| Key finding | Ibogaine-treated rats showed weaker aversion to a withdrawal-paired chamber and fewer somatic withdrawal reactions than saline-treated rats after naloxone-precipitated withdrawal from two morphine treatments. |
Abstract
It has been reported that ibogaine interferes with somatic withdrawal reactions in rats chronically treated with morphine. The present experiments demonstrated that ibogaine also interferes with motivational withdrawal reactions and somatic withdrawal reactions in rats treated with morphine on only two occasions. On each of two conditioning trials, naloxone was administered 24 h following an injection of morphine. Four hours prior to each naloxone administration, rats were injected with either ibogaine or saline. In two experiments, ibogaine interfered with naloxone-precipitated withdrawal. In Experiment 1, ibogaine-treated rats displayed a weaker aversion to the withdrawal-paired chamber, and in Experiment 2, ibogaine-treated rats displayed fewer somatic withdrawal reactions than did saline treated rats.