Acute ibogaine injection induces expression of the immediate early genes, egr-1 and c-fos, in mouse brain.
Brain research. Molecular brain research December 10, 1999 DOI: 10.1016/s0169-328x(99)00283-1 via PubMed
Summary
AI-generated from the abstractA single injection of ibogaine in adult male mice significantly increased the activity of two immediate early genes, egr-1 and c-fos, in several brain regions within 30 minutes. Egr-1 messenger RNA rose in the nucleus accumbens, caudate-putamen, frontal cortex, septum, dentate gyrus, and CA3 region of the hippocampus. C-fos gene expression increased in the caudate-putamen, frontal cortex, dentate gyrus, septum, and CA1 region of the hippocampus. The authors suggest this gene activation may partly stem from ibogaine's stimulant properties, similar to other psychostimulants.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Adult male C57 mice |
| Intervention | Ibogaine |
| Duration | 30 minutes after injection |
| Topics | Ibogaine |
| Keywords | Psychoactive compound Psychedelic Gene expression Genetic activation |
| Citations | 13 |
| Key finding | A single acute injection of ibogaine induces immediate early gene expression (egr-1 and c-fos) in multiple brain regions of mice, possibly related to its stimulant properties. |
Abstract
The aim of the present study was to evaluate if an acute injection of ibogaine (IBO) induces immediate early gene expression in different regions of mouse brain. Adult male C57 mice received a single injection of IBO and were perfused transcardially with 1% paraformaldehyde 30 min after the drug administration. A single injection of IBO produced a significant increase of egr-1 messenger RNA induction in nucleus accumbens (NAc), caudate-putamen (CPu), frontal cortex (FCx), septum, dentate gyrus (DG) and CA3 region of hippocampus, whereas c-fos gene was induced in CPu, FCx, DG, septum and CA1 region of hippocampus. This gene expression may be due, in part, to the stimulant properties of IBO, as we found with other psychostimulants.