Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration.
Helena Carmo, Douwe De Boer, Fernando Remião, Félix Carvalho, Lesseps A Dos Reys, Maria De Lourdes Bastos
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences November 25, 2004 DOI: 10.1016/j.jchromb.2004.08.026 via PubMed
Summary
AI-generated from the abstractThe psychoactive drug 2C-B, sold as 'Ecstasy', is metabolized in mice, producing several metabolites detectable in urine by GC/MS. Unchanged 2C-B and these metabolites were identified, providing data that may help understand the drug's biological and toxicological effects and aid forensic analysis of samples from human abusers.
Study at a glance
| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Mice |
| Intervention | 2C-B |
| Keywords | Drug metabolism Forensic toxicology Psychoactive drugs Animal studies |
| Citations | 32 |
| Key finding | Unchanged 2C-B and several metabolites were identified in mouse urine by GC/MS. |
Abstract
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers.