Time-dependent interactions between iboga agents and cocaine.
I M Maisonneuve, K E Visker, G L Mann, U K Bandarage, M E Kuehne, S D Glick
European journal of pharmacology October 8, 1997 DOI: 10.1016/s0014-2999(97)01231-4 via PubMed
Summary
AI-generated from the abstractIbogaine and two related compounds (noribogaine and 18-methoxycoronaridine) both inhibit and later enhance cocaine-induced hyperactivity in rats, depending on timing. When given 1 hour before cocaine, all three agents reduced the hyperactivity caused by cocaine. When given 19 hours before cocaine, they instead amplified it. These opposite, time-dependent effects explain conflicting findings in earlier research and were not caused by the drugs' own effects on movement.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Ibogaine Noribogaine 18-Methoxycoronaridine |
| Dose | 40 mg/kg |
| Duration | 3 hours of motor activity monitoring after cocaine administration |
| Citations | 20 |
| Key finding | Ibogaine, noribogaine, and 18-methoxycoronaridine acutely inhibit and later potentiate cocaine-induced hyperactivity in rats. |
Abstract
The purpose of this study was to clarify the effects of iboga agents on cocaine-induced hyperactivity. Both inhibition and enhancement of cocaine-induced activity by ibogaine have been reported. In the present study, rats were treated with either ibogaine (40 mg/kg, i.p.), noribogaine (40 mg/kg, i.p.), 18-methoxycoronaridine (40 mg/kg, i.p.), or saline, 1 or 19 h prior to the administration of cocaine (20 mg/kg, i.p.) or saline. Motor activity was monitored thereafter for 3 h. All three iboga agents had acute inhibitory effects and delayed potentiating effects on cocaine-induced hyperactivity. These time-dependent effects, which could not be attributed to the motor activity induced by the iboga agents alone, account for divergent results reported in the literature.