Gangliosides attenuate stress-induced changes on body weight, motor activity and on the behavioral response to 5-methoxy-N,N-dimethyltryptamine.
L M Cancela, M Volosin, V A Molina
Brain research bulletin January 1, 1996 DOI: 10.1016/0361-9230(96)00040-8 via PubMed
Summary
AI-generated from the abstractInjecting gangliosides before repeated restraint stress in rats reversed stress-induced reductions in motor activity and body weight, and enhanced certain behavioral responses linked to serotonin receptors. A single stress session or three days of stress alone did not change the response to a serotonin-receptor drug, but combining gangliosides with three days of stress increased forepaw treading and hindlimb abduction. Gangliosides may speed up adaptive changes in serotonin-1 sites and lessen some aftereffects of stress.
Study at a glance
| Characteristics | Controlled experiment Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Gangliosides |
| Dose | 30 mg/kg IP |
| Duration | 3 days of daily restraint sessions with ganglioside injection 2 hours before each session |
| Citations | 14 |
| Key finding | Ganglioside treatment combined with three days of repeated restraint stress reversed the stress-induced decrease in motor activity and body weight, and enhanced forepaw treading and hindlimb abduction in response to 5-MeODMT. |
Abstract
The major goal of this study was to evaluate the influence of gangliosides (GANG) treatment on the onset of adaptive changes and the sequelae induced by stress exposure. With this purpose, the behavioral response to 5-methoxy-N,N-dimethyltryptamine (5-MeODMT, 5 mg/kg, IP) and motor activity were evaluated in rats previously submitted either to a single restraint session (2 h) or to a daily restraint event for 3 consecutive days, combined or not to GANG administration (30 mg/kg IP). GANG was always injected 2 h before stress exposure. In addition, differences in body weights were recorded throughout the experiments. A similar behavioral response after 5-MeODMT was observed between saline (SAL) and GANG unstressed rats. Exposure to one or three restraint sessions did not modify the behavioral response to 5-MeODMT, whereas the association of GANG and stress during 3 consecutive days enhanced forepaw treading and hindlimb abduction. SAL-treated animals submitted to a single or to three stressful stimuli showed reduced locomotion and rearing. The combination of GANG and stress for 3 days, but not after a unique association, reversed the decrease on motor activity induced by the aversive experience. The decrease of body weights produced by one or three stress sessions was recovered only in animals treated with GANG and stress for 3 days. These findings suggest that GANG may accelerate the onset of adaptive changes on 5-HT1 sites and attenuate certain sequelae induced by previous stress experience.