Behavioral and electroencephalographic effects of a serotonin receptor agonist (5-methoxy-N,N-dimethyltryptamine) in a feline model of photosensitive epilepsy.
Y Wada, H Hasegawa, M Nakamura, N Yamaguchi
Neuroscience letters April 13, 1992 DOI: 10.1016/0304-3940(92)90485-p via PubMed
Summary
AI-generated from the abstractA serotonin receptor agonist, 5-MeODMT, suppresses light-triggered muscle jerks but not abnormal EEG activity in kindled cats. At a dose of 4 mg/kg, the drug reduced photically induced myoclonus for 30 to 60 minutes after injection, accompanied by behavioral signs resembling serotonin syndrome. The findings indicate that serotonin, acting through 5-HT1 receptors, plays a key role in photosensitive epilepsy.
Study at a glance
| Characteristics | Experimental animal study Peer reviewed |
|---|---|
| Population | Lateral geniculate-kindled cats |
| Interventions | 5-methoxy-N N-dimethyltryptamine (5-MeODMT) |
| Dose | 4 mg/kg |
| Citations | 21 |
| Key finding | 5-MeODMT at 4 mg/kg significantly suppressed photically induced myoclonus but not paroxysmal EEG activity, suggesting an inhibitory effect via 5-HT1 receptors. |
Abstract
The effects of a serotonin (5-HT) receptor agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), on epileptic photosensitivity were studied in the lateral geniculate-kindled cat. 5-MeODMT at 4 mg/kg significantly suppressed photically induced myoclonus, but not paroxysmal EEG activity, at 0.5-1 h after injection. This antiepileptic effect was seen in association with the appearance of behavioral signs similar to those seen in the 5-HT syndrome. The present data provide further evidence that 5-HT plays an important role in photosensitive epilepsy, and suggest that the inhibitory effect of 5-MeODMT on photosensitivity results from its agonist action at 5-HT1 receptors.