Chronic phenytoin and the stereotyped motor response induced by 5-methoxy-N,N-dimethyltryptamine in rats.
Brain research February 11, 1985 DOI: 10.1016/0006-8993(85)90052-6 via PubMed
Summary
AI-generated from the abstractLong-term administration of phenytoin (PHT) to male rats for 20 consecutive days reduced the intensity of a stereotyped motor response induced by the serotonin agonist 5-MDMT at 3 mg/kg when tested on day 21, but this effect was absent by day 28. A single injection of PHT did not alter the motor response. The authors suggest that PHT increases the functional availability of serotonin before its receptors, leading to serotonin receptor subsensitivity.
Study at a glance
| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Male Sprague-Dawley rats |
| Interventions | Phenytoin 5-methoxy-N N-dimethyltryptamine |
| Dose | 25 mg/kg |
| Duration | 20 consecutive days of phenytoin injections, with behavioral testing on days 21 and 28 |
| Citations | 1 |
| Key finding | Long-term phenytoin administration decreased the intensity of a stereotyped motor response induced by 5-MDMT at 3 mg/kg on day 21 but not on day 28, suggesting serotonin receptor subsensitivity. |
Abstract
Male Sprague-Dawley rats were injected with phenytoin (PHT) once a day for 20 consecutive days and then tested as to their response to 5-methoxy-N,N-dimethyltryptamine (5-MDMT), a 5-hydroxytryptamine (5-HT) agonist, at 1 and 3 mg/kg on days 21 and 28. It was found that long-term PHT administration decreased the intensity of a stereotyped motor response induced by 5-MDMT (3 mg/kg) on day 21 but not on day 28. A single injection of PHT (25 mg/kg) did not modify the motor response induced by 5-MDMT (3 mg/kg) on day 21 but not on day 28. A single injection of PHT (25 mg/kg) did not modify the motor response induced by 5-MDMT (1.7, 3.2 mg/kg). It is suggested that PHT increases the functional availability of 5-HT before its receptors, and thereby causes 5-HT receptor subsensitivity.