Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD.
R Young, J A Rosecrans, R A Glennon
Life sciences June 14, 1982 DOI: 10.1016/0024-3205(82)90446-5 via PubMed
Summary
AI-generated from the abstractRats trained to distinguish injections of 5-OMe DMT or LSD from saline showed that the effects of these drugs are interchangeable: animals trained on one drug recognized the other. The serotonin antagonist BC-105 reduced the effects of both drugs, but the pattern of this reduction differed between them, suggesting that while both drugs act through the serotonin system, they interact with it in somewhat different ways.
Study at a glance
| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5-OMe DMT LSD BC-105 |
| Dose | 5-OMe DMT 1.5 mg/kg, LSD 0.096 mg/kg |
| Citations | 26 |
| Key finding | The discriminative stimulus effects of 5-OMe DMT and LSD generalize to each other and are both attenuated by the serotonin antagonist BC-105, but the pattern of antagonism differs between the two drugs. |
Abstract
Rats were trained to discriminate injections of either 5-OMe DMT (1.5 mg/kg) or LSD (0.096 mg/kg) from saline in a two-lever drug discrimination task. After stable discrimination performances were attained (greater than 85%) in each group, dose-response generalizations between the two groups of animals were examined. The results revealed that the 5-OMe DMT-stimulus response generalized to LSD and that the LSD-stimulus response generalized to 5-OMe DMT. Furthermore, both the 5-OMe DMT-stimulus and the LSD-stimulus could be significantly attenuated by the serotonin antagonist BC-105. However, the pattern of the dose-related antagonism by BC-105 was different between the drug stimuli. It was concluded that while the discriminative stimulus effects of 5-OMe DMT and LSD may be mediated via a common serotonergic system, the receptor interaction of these agents within that pharmacological system may be somewhat different.