The effects of psilocybin on cognition and emotional processing in healthy adults and adults with depression: a systematic literature review

Psilocybin temporarily changes specific cognitive functions in a way that depends on dose and time, affecting localized brain processes rather than overall cognition. The authors note that current research has important methodological limitations, so more studies are needed—especially those using standardized methods, focusing on depression, and tracking effects over longer periods.

Study at a glance

Abstract

Psilocybin acutely alters several cognitive domains, with a localized rather than global focus, in a dose- and time-dependent manner. However, the significant methodological constraints call for further research, in the context of depression and with standardized protocols, with longitudinal studies also imperative.