Where do the symptoms come from in depression? Topography and dynamics matter

A commentary on a study about brain dynamics that predict response to psilocybin for treatment-resistant depression. The original study by Vohryzek and colleagues investigated how brain activity patterns before and during psilocybin treatment might identify which patients with treatment-resistant depression are likely to benefit. The commentary discusses the implications of these findings for understanding how psychedelics work in the brain and for developing personalized treatment approaches.

Study at a glance

Abstract

This scientific commentary refers to ‘Brain dynamics predictive of response to psilocybin for treatment-resistant depression’, by Vohryzek et al. (https://doi.org/10.1093/braincomms/fcae049)