Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin
Devon Stoliker, Leonardo Novelli, Adeel Razi, Franz X. Vollenweider, Gary F. Egan, Katrin H. Preller
Biological Psychiatry January 5, 2024 DOI: 10.1016/j.biopsych.2024.01.002 via OpenAlex
Summary
AI-generated from the abstractTemporary reduction in amygdala signaling is linked to changes in how brain networks connect at rest. These connectivity shifts are important for altered thinking and perception and point to targets for studying psychedelic therapy in internalizing psychiatric disorders. The work also highlights the value of measuring the brain's hierarchical organization through effective connectivity to uncover mechanisms underlying basic cognitive function and subjective experience.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Amygdala Cognition Neuroscience Resting State FMRI |
| Citations | 42 |
| Key finding | Temporary amygdala signal attenuation is associated with mechanistic changes to resting-state network connectivity, which are significant for altered cognition and perception and suggest targets for psychedelic therapy research. |
Abstract
Our findings suggest that temporary amygdala signal attenuation is associated with mechanistic changes to resting-state network connectivity. These changes are significant for altered cognition and perception and suggest targets for research investigating the efficacy of psychedelic therapy for internalizing psychiatric disorders. More broadly, our study suggests the value of quantifying the brain's hierarchical organization using effective connectivity to identify important mechanisms for basic cognitive function and how they are integrated to give rise to subjective experiences.