Mindfulness, coping, and optimism as mechanisms of change in the 3RP-NF intervention.
Victoria A Grunberg, Jafar Bakhshaie, Heena Manglani, Julia Hooker, Elizabeth A Rochon, Ana-Maria Vranceanu
Journal of clinical psychology February 1, 2024 DOI: 10.1002/jclp.23623 via PubMed
Summary
AI-generated from the abstractAmong 114 adults with neurofibromatosis (NF), a chronic neurogenetic condition that increases risk for poor quality of life, depression, and anxiety, improvements in quality of life were most explained by improved coping, followed by mindfulness and optimism. Improvements in depression and anxiety were most explained by mindfulness, followed by optimism, but were not explained by coping. Targeting mindfulness, coping, and optimism in psychosocial interventions may be a promising way to improve the lives of adults with NF.
Study at a glance
| Characteristics | Secondary analysis of an intervention study Peer reviewed |
|---|---|
| Sample size | 114 |
| Population | Adults with neurofibromatosis, ages 18-70, 72.80% female, 81.58% White |
| Topics | Anxiety Depression |
| Keywords | Mechanisms of change Neurofibromatosis Quality of life |
| Citations | 4 |
| Key finding | Improvements in quality of life were most explained by coping, followed by mindfulness and optimism; improvements in depression and anxiety were most explained by mindfulness, followed by optimism, but not by coping. |
Abstract
Neurofibromatosis (NF) is chronic neurogenetic condition that increases risk for poor quality of life, depression, and anxiety. Given the lack of biomedical treatments, we developed the "Relaxation Response Resiliency for NF" (3RP-NF) program to improve psychosocial outcomes among adults with NF. To move toward effectiveness testing, we must understand mechanisms that explained treatment effects. We tested whether our hypothesized mechanisms of change-mindfulness, coping, and optimism-mediated improvements in quality of life, depression, and anxiety among adults in the 3RP-NF program (N = 114; ages 18-70; 72.80% female; 81.58% White). We conducted mixed-effects models to assess whether these mechanisms uniquely mediated outcomes. Improvements in quality of life were most explained by coping, (b = 0.97, SE = 0.28, CI [0.45, 1.56]), followed by mindfulness (b = 0.46, SE = 0.17, CI [0.15, 0.82]) and optimism (b = 0.39, SE = 0.12, CI [0.17, 0.65]). Improvements in depression and anxiety were most explained by mindfulness (b = -1.52, SE = 0.38, CI [-2.32, -0.85], CSIE = -0.26; b = -1.29, SE = 0.35, CI [-2.04, -0.67], CSIE = -0.23), followed by optimism (b = 0.39, SE = 0.12, CI [0.17, 0.65]; b = -0.49, SE = 0.20, CI [-0.91, -0.13]), but were not explained by coping (b = 0.22, SE = 0.43, CI [-0.62, 1.07]; b = 0.06, SE = 0.46, CI [-0.84, 0.97]), respectively. Targeting mindfulness, coping, and optimism in psychosocial interventions may be a promising way to improve the lives of adults with NF.