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Anesthetic Management of Atypical Toxic Epidermal Necrolysis in a Six-Month-Old Patient Undergoing Burn Surgery: A Case Report.

Cassidy Chau, Anthony Q Dang, Thong Nguyen

Cureus May 1, 2025 DOI: 10.7759/cureus.83952 via PubMed

Summary

AI-generated from the abstract

Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin condition causing widespread skin detachment and mucous membrane damage. A six-month-old male with atypical TEN was transferred from a hospital in Mexico to a US facility, presenting with widespread full-thickness necrotic wounds but no bullae or sloughing. The unclear diagnosis made anesthetic planning challenging due to the need for prolonged intubation after extensive burn debridement and grafting. This case report emphasizes perioperative assessment, induction strategy, airway management, resuscitation, and pain control for atypical TEN patients.

Study at a glance

Characteristics Case report Peer reviewed
Sample size 1
Population Six-month-old male with atypical toxic epidermal necrolysis
Interventions extensive burn debridement and grafting surgery prolonged intubation
Keywords Burn resuscitation Fiberoptic intubation Ketamine and dexmedetomidine Lyell's syndrome Stevens-johnson syndrome
Key finding Atypical TEN in an infant without bullae or sloughing complicates anesthetic planning for burn debridement and grafting.

Abstract

Toxic epidermal necrolysis (TEN) is a rare, life-threatening skin condition that involves widespread skin detachment and mucous membrane damage. We present a case of a six-month-old male with atypical TEN transferred from an outside hospital in Mexico to our facility. The patient had widespread full-thickness necrotic wounds but no bullae or sloughing. Since the diagnosis was unclear at the time, it posed a significant challenge to make an appropriate anesthetic plan given the need for prolonged intubation after extensive burn debridement and grafting surgery. This case report highlights the importance of perioperative assessment, induction strategy, airway management, resuscitation, and pain control in an atypical TEN patient.

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