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Neurobehavioral pathways linking socioeconomic status hardship to suicide risk versus resilience in young adolescents: the roles of sleep health and default mode network connectivity.

Assaf Oshri, Cullin J Howard, Steven M Kogan, Linhao Zhang, Charles F Geier, Brian W Bauer, Ellen House

Translational psychiatry November 24, 2025 DOI: 10.1038/s41398-025-03710-y via PubMed

Summary

AI-generated from the abstract

Socioeconomic hardship increases the risk of suicidal thoughts and behaviors in adolescents, partly through shorter sleep duration. A study of 11,878 youth from the Adolescent Brain Cognitive Development Study found that higher levels of hardship predicted more suicidal ideation and attempts. Shorter sleep acted as a pathway linking hardship to suicidal thoughts, but this indirect effect was weaker in adolescents with higher coherence in the brain's Default Mode Network. The findings suggest that sleep health is a mechanism connecting economic adversity to suicide risk, and that DMN coherence may serve as a neuroprotective factor supporting resilience.

Study at a glance

Characteristics Observational cohort Peer reviewed
Sample size 11,878
Population Adolescents from the Adolescent Brain Cognitive Development (ABCD) Study
Duration Three waves
Keywords Suicidal thoughts Suicide risk Mental health impacts Adolescent resilience Youth resilience
Key finding Shorter sleep duration mediated the association between socioeconomic hardship and suicidal ideation, while high Default Mode Network coherence weakened this indirect effect.

Abstract

Socioeconomic hardship (SES-H) is a known risk factor for adolescent suicidal thoughts and behaviors (STB). This study examined sleep health as a pathway linking SES-H to suicide risk and evaluated the moderating role of Default Mode Network (DMN) coherence. Data came from three waves of the Adolescent Brain Cognitive Development (ABCD) Study (N = 11,878). Increased SES-H predicted greater suicidal ideation and attempts. Shorter sleep duration mediated the association with ideation, while high DMN coherence attenuated the indirect effect of SES-H on ideation via sleep. Findings highlight sleep health as a mechanism connecting socioeconomic adversity to suicidality and suggest DMN coherence may function as a neuroprotective factor for youth resilience.

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