Reactivations Associated with the Use of 5-MeO-DMT Among Spanish-Speaking Individuals: Prevalence, Predictors, and Emotional Valence.
A.M. Ortiz Bernal, C.L. Raison, R.L. Lancelotta, C Timmermann, N.D Sepeda, A.K Davis
J Psychoactive Drugs October 23, 2025 DOI: 10.1080/02791072.2025.2577305 via PubMed
Summary
AI-generated from the abstractAmong Spanish-speaking individuals who have used 5-MeO-DMT, spontaneous re-experiences of the substance's effects—often called reactivations—are relatively common, typically non-distressing, and often positively valenced. The study reports the prevalence of these reactivations and identifies predictors such as higher doses and greater emotional impact during the original experience. Most users describe these residual effects as neutral or positive, contributing to lasting well-being rather than distress.
Study at a glance
| Characteristics | Survey Peer reviewed |
|---|---|
| Sample size | 380 |
| Population | Spanish-speaking individuals who have used 5-MeO-DMT |
| Intervention | 5-MeO-DMT |
| Topics | 5-MeO-DMT |
| Keywords | Psychedelic Entheogen Psychoactive substance Reactivations |
| Key finding | Reactivations after 5-MeO-DMT use are prevalent, generally non-distressing, and often positive, with higher dose and emotional intensity during the original experience predicting their occurrence. |
Abstract
Reactivations Associated with the Use of 5-MeO-DMT Among Spanish-Speaking Individuals: Prevalence, Predictors, and Emotional Valence.