Serotonin, Psilocybin, and Body Dysmorphic Disorder

Psilocybin-assisted psychotherapy may reduce symptoms of body dysmorphic disorder (BDD) by altering how individuals perceive and evaluate their own appearance. In a small open-label pilot study, participants with BDD received two doses of psilocybin combined with psychotherapy. Results suggest clinically meaningful reductions in BDD symptom severity and improvements in insight and quality of life at post-treatment and at 3-month follow-up. No serious adverse events were reported, though transient anxiety occurred during drug sessions. These preliminary findings indicate psilocybin-assisted therapy could be a promising treatment for BDD, a condition with limited effective options.

Study at a glance

Abstract

Cognitive Neuropsychiatry Research Unit, Mental Health Research Institute, Parkville, Victoria, Australia.