Psilocybin ameliorates neuropathic pain-like behaviour in mice and facilitates the gabapentin-mediated analgesia
Maria Maiarù, Tatum Askey, Daniel Allen-Ross, Reena Lasrado, Gary Gilmour, Stephen P. Hunt, Francesco Tamagnini, Maqsood Ahmed, Gary J. Stephens
Research Square September 19, 2024 DOI: 10.21203/rs.3.rs-5026806/v1 via OpenAlex
Summary
AI-generated from the abstractA single dose of psilocybin produced a sustained reduction in pain sensitivity in a mouse model of chronic neuropathic pain. Additionally, this single dose dramatically increased the pain-relieving effect of gabapentin, a common neuropathic pain medication. These findings suggest that psilocybin may induce lasting changes in neural network processing that enhance the effectiveness of existing treatments.
Study at a glance
| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Population | Mouse model of chronic neuropathic pain |
| Interventions | Psilocybin Gabapentin |
| Dose | single dose |
| Topics | Psilocybin |
| Keywords | Gabapentin Neuropathic pain Medicine Anesthesia |
| Citations | 2 |
| Key finding | A single dose of psilocybin produced sustained anti-nociceptive effects and dramatically increased the anti-nociceptive potential of gabapentin in a mouse model of chronic neuropathic pain. |
Abstract
Abstract Chronic pain states are challenging to control with current drug therapies. Here, we demonstrate that a single dose of psilocybin can produce a sustained anti-nociceptive effect in a mouse model of chronic neuropathic pain. Beyond this, the single dose of psilocybin caused a dramatic increase in the anti-nociceptive potential of gabapentin, a widely used treatment for neuropathic pain, such data are suggestive of establishment of longer lasting changes in network processing.