Extending ketamine's antidepressant effects.

Ketamine's rapid antidepressant effects are limited in duration. Boosting a specific intracellular signaling pathway, the mammalian target of rapamycin (mTOR) pathway, can preserve the antidepressant response to ketamine in animal models. Activating this pathway extends the duration of ketamine's effects, suggesting a potential strategy for prolonging therapeutic benefits in depression treatment.

Study at a glance

Abstract

Boosting an intracellular signaling pathway preserves the antidepressant response to ketamine.