Neural correlates of the personality factor openness before and after psilocybin-therapy to depressed patients
Zenodo (CERN European Organization for Nuclear Research) August 31, 2019 DOI: 10.5281/zenodo.7796283 via OpenAlex
Summary
AI-generated from the abstractIn treatment-resistant depression, openness to experience and its neural correlates were examined before and after a psilocybin-assisted intervention. The study aimed to extend personality neuroscience findings from healthy individuals to depressed populations and to uncover neural mechanisms that might mediate clinical improvements. The results suggest that changes in openness are linked to specific brain activity patterns, potentially underlying therapeutic benefits.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Individuals with treatment-resistant depression |
| Intervention | Psilocybin-assisted intervention |
| Topics | Psilocybin |
| Keywords | Openness to experience Clinical psychology Psychotherapist Personality |
| Key finding | Changes in openness to experience are associated with neural correlates that may mediate clinical improvements following psilocybin-assisted therapy. |
Abstract
This document is my Master's Thesis for the Research Master Cognitive Neuroscience program at Maastricht University. The present study investigated the relationship between openness and its neural correlates in treatment-resistant depression preceding and following a psilocybin-assisted intervention, to (i) extent the findings of personality neuroscience from healthy to depressed population and (ii) unfold the neural mechanisms that could be mediating clinical improvements.