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Insights into psilocybin use among people with bipolar disorder: A thematic analysis of Reddit posts

Laura Mills, Susan L. Rossell, Sean Carruthers

Journal of Affective Disorders January 20, 2026 DOI: 10.1016/j.jad.2026.121220 via OpenAlex

Summary

AI-generated from the abstract

Psilocybin use among people with bipolar disorder is associated with both benefits and risks. Analysis of 354 Reddit posts and comments revealed four themes: mania, depression, mixed experiences, and broader perspectives. Some users reported reduced depression symptoms and shifts in perspective, but others described increased or new mania, psychosis, and worsened depression. The findings suggest that while psilocybin may help some individuals with bipolar disorder, it also carries potential for adverse mental health effects.

Study at a glance

Characteristics Thematic analysis Peer reviewed
Sample size 354
Population Reddit users with bipolar disorder who shared first-hand psilocybin experiences
Intervention Psilocybin
Topics Psilocybin
Keywords Thematic analysis Mania Psychosis Bipolar disorder
Key finding Psilocybin use among individuals with bipolar disorder is linked to both reduced depression and perspective shifts, as well as increased mania, psychosis, and depression.

Abstract

Psilocybin has been reported to decrease depression symptoms among individuals with bipolar disorder (BD), but has also been associated with reports of mania, psychosis and increased depression. With increasing recreational use of psilocybin, and the potential for psilocybin to be used as a treatment for depression, a better understanding of the risks and benefits of this psychedelic among individuals with BD is warranted. Individuals have used social media sites like Reddit to share their experiences with psilocybin, providing an opportunity to understand a range of perspectives and experiences. The current study aimed to further explore psilocybin experiences as shared on Reddit, with a focus on posts related to BD. A thematic analysis of Reddit posts and comments was undertaken, with a focus on those identified with search terms, "bipolar" AND "psilocybin" OR "mushrooms". A total of 354 comments with a first-hand psilocybin experience were identified and included in the thematic analysis which revealed four core themes: (1) mania, (2) depression, (3) mixed experiences, and (4) broader perspectives. Psilocybin was reported to have benefits in some comments, including reduced depression symptoms and shifts in perspective about oneself and/or the world. However, reports of increased or new mania and psychosis symptoms were also reported, as well as increased depression. While psilocybin may benefit some individuals with BD, there may be potential for increased mania, psychosis and depression symptoms. Understanding the factors that contribute positive and negative outcomes among individuals with BD will be important in future research.

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