Replication Data for: Calcium Activation Mechanism of a Noncanonical Aromatic L-Amino Acid Decarboxylase from Psilocybin Mushroom
CUHK Research Data Repository January 1, 2025 DOI: 10.48668/wdgxne via OpenAlex
Summary
AI-generated from the abstractPsilocybin, the psychoactive compound in magic mushrooms, is produced by an enzyme called PsiD, which belongs to a class of enzymes that typically require a chemical tag to function. This study shows that PsiD instead uses calcium ions to become active, a novel mechanism for this enzyme family. The authors determined the three-dimensional structure of PsiD and demonstrated that calcium binding triggers a shape change that allows the enzyme to work. This finding explains how the mushroom makes psilocybin and reveals a new way that cells can control enzyme activity.
Study at a glance
| Characteristics | Structural biology study Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Mechanism biology Calcium Replication statistics Enzyme activator |
| Key finding | The aromatic L-amino acid decarboxylase PsiD from psilocybin mushroom is activated by calcium binding rather than by the pyruvoyl modification typical of its enzyme family. |
Abstract
Replication Data for: Calcium Activation Mechanism of a Noncanonical Aromatic L-Amino Acid Decarboxylase from Psilocybin Mushroom