Psilocybin-Assisted Therapy for Trauma-Related Disorders: A Scoping Review of a Depression-Dominated Evidence Base with Implications for Intimate Partner Violence-Related PTSD
Hancock, Mackenzie, Shambhu Prasad Adhikari, Getz, Nicole
Open Science Framework January 1, 2025 DOI: 10.17605/osf.io/ar2s4 via OpenAlex
Summary
AI-generated from the abstractPsilocybin-assisted therapy shows emerging promise for treating trauma-related conditions including PTSD, depression, and persistent post-concussion symptoms, with potential relevance for survivors of intimate partner violence who have sustained brain injury. This scoping review mapped research from 2015 to 2025 across multiple databases and grey literature, identifying gaps in the evidence and highlighting the need for future clinical trials specifically targeting IPV survivors. The review did not report quantitative results but provides a framework for designing such trials.
Study at a glance
| Characteristics | Scoping review Peer reviewed |
|---|---|
| Intervention | psilocybin-assisted therapy |
| Keywords | Domestic violence Posttraumatic stress Psychiatry Psychotherapist Clinical psychology |
| Key finding | Psilocybin-assisted therapy has emerging evidence for treating trauma-related disorders, but research on its use for IPV survivors with brain injury is lacking and requires further clinical trials. |
Abstract
This scoping review examines the emerging evidence for psilocybin-assisted therapy (PAP) in treating trauma-related disorders such as posttraumatic stress disorder (PTSD), depression, and persistent post-concussion symptoms (PPCS), with specific implications for intimate partner violence (IPV)-related brain injury and PTSD. Guided by PRISMA-ScR methodology, we systematically searched Medline, Embase, CINAHL, PsycINFO, and grey literature from 2015–2025 to map existing research, identify gaps, and inform the design of future clinical trials of PaT for IPV survivors.