Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans
Suresh Muthukumaraswamy, Alexander D. Shaw, Laura E. Jackson, Judith Hall, Rosalyn Moran, Neeraj K. Saxena
Journal of Neuroscience August 19, 2015 DOI: 10.1523/jneurosci.0903-15.2015 via OpenAlex
Summary
AI-generated from the abstractSubanesthetic doses of ketamine, similar to those used in antidepressant studies, increase anterior theta and gamma power but decrease posterior theta, delta, and alpha power, as shown by magnetoencephalographic recordings. Dynamic causal modeling revealed a decrease in NMDA and AMPA-mediated frontal-to-parietal connectivity, with AMPA-mediated changes persisting up to 50 minutes after infusion ceased, even after perceptual distortions had ended. A decrease in gain of parietal pyramidal cells correlated with participants' self-reports of blissful state. These alterations in frontoparietal connectivity patterns may be important in generating the antidepressant response to ketamine.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Human participants |
| Intervention | Ketamine |
| Dose | subanesthetic doses |
| Topics | Ketamine |
| Keywords | Neuroscience Nmda receptor Ampa receptor Psychology |
| Citations | 244 |
| Key finding | Subanesthetic ketamine alters frontoparietal connectivity and neural oscillations in a pattern that may underlie its antidepressant effects. |
Abstract
In this paper, we found that subanesthetic doses of ketamine, similar to those used in antidepressant studies, increase anterior theta and gamma power but decrease posterior theta, delta, and alpha power, as revealed by magnetoencephalographic recordings. Dynamic causal modeling of frontoparietal connectivity changes with ketamine indicated a decrease in NMDA and AMPA-mediated frontal-to-parietal connectivity. AMPA-mediated connectivity changes were sustained for up to 50 min after ketamine infusion had ceased, by which time perceptual distortions were absent. The results also indicated a decrease in gain of parietal pyramidal cells, which was correlated with participants' self-reports of blissful state. The alterations in frontoparietal connectivity patterns we observe here may be important in generating the antidepressant response to ketamine.