GLC-Mass Spectral Analysis of Psilocin and Psilocybin
David B. Repke, Dale Thomas Leslie, Daniel Mandell, Nicholas G. Kish
Journal of Pharmaceutical Sciences May 1, 1977 DOI: 10.1002/jps.2600660539 via OpenAlex
Summary
AI-generated from the abstractPsilocin and psilocybin, two hallucinogenic indoles, were analyzed using a combined gas-liquid chromatography–mass spectrometry technique after conversion to their trimethylsilyl derivatives. The method was applied to an extract of the mushroom Psilocybe cubensis (Earle) Sing., enabling detection and identification of both compounds.
Study at a glance
| Characteristics | Method development and analytical study Peer reviewed |
|---|---|
| Population | Extract of Psilocybe cubensis (Earle) Sing. |
| Topics | Psilocybin |
| Keywords | Hallucinogen Mass spectrometry Spectral analysis Trimethylsilyl |
| Citations | 31 |
| Key finding | The combined GLC-mass spectrometry technique with trimethylsilyl derivatization successfully analyzed psilocin and psilocybin in an extract of Psilocybe cubensis. |
Abstract
With the combined technique of GLC-mass spectrometry, psilocin and psilocybin, two hallucinogenic indoles, were analyzed as their trimethylsilyl derivatives. The method was applied to these two components in an extract of Psilocybe cubensis (Earle) Sing.