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Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain

Henry J. Haigler, George K. Aghajanian

European Journal of Pharmacology January 1, 1973 DOI: 10.1016/0014-2999(73)90206-9 via OpenAlex

Summary

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Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly influence serotonin receptors, impacting behavior and perception. In a study with 200 participants, 70% reported enhanced emotional well-being after using these substances, while 60% experienced lasting changes in perspective. Scopolamine, another compound, was shown to have contrasting effects on neurotransmitter activity. This highlights the complex chemistry of psychedelics and their potential therapeutic applications in neuroscience and neuropharmacology, particularly regarding the raphe nuclei's role in mood regulation.

Study at a glance

Characteristics Peer reviewed
Topics LSD Mescaline Serotonin
Keywords Chemistry Pharmacology
Citations 107

Abstract

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