Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans
Patrick C. Dolder, Yasmin Schmid, Manuel Haschke, Katharina Rentsch, Matthias E. Liechti
The International Journal of Neuropsychopharmacology June 24, 2015 DOI: 10.1093/ijnp/pyv072 via OpenAlex
Summary
AI-generated from the abstractOral lysergic acid diethylamide (LSD) shows dose-proportional pharmacokinetics, with peak concentrations reached about 1.5 hours after ingestion and a terminal half-life of approximately 3.6 hours. The drug's effects are closely related to its blood concentration, with subjective effects lasting up to 12 hours. These findings provide a reference for clinical studies and for assessing LSD intoxication.
Study at a glance
| Characteristics | Pharmacokinetic study Peer reviewed |
|---|---|
| Population | Healthy adults |
| Intervention | Lysergic acid diethylamide |
| Topics | LSD |
| Keywords | Pharmacokinetics Urine Pharmacology Active metabolite |
| Citations | 110 |
| Key finding | LSD exhibits dose-proportional pharmacokinetics with a terminal half-life of 3.6 hours and effects lasting up to 12 hours. |
Abstract
These first data on the pharmacokinetics and concentration-effect relationship of oral lysergic acid diethylamide are relevant for further clinical studies and serve as a reference for the assessment of intoxication with lysergic acid diethylamide.