Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
Piotr Popik, Adam S. Hogendorf, Ryszard Bugno, Shaun Yon‐seng Khoo, Paweł Zajdel, Natalia Malikowska‐racia, Agnieszka Nikiforuk, Joanna Gołębiowska
Psychopharmacology March 2, 2022 DOI: 10.1007/s00213-021-06020-5 via OpenAlex
Summary
AI-generated from the abstractTime underestimation caused by (S)-ketamine may be linked to its antidepressant effects, but this came with severe behavioral disruption. The authors propose that behavioral disruption induced by psychedelics objectively indicates their psychotomimetic-like actions.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Intervention | (S)-ketamine |
| Topics | Ketamine Psilocybin |
| Keywords | Serial reaction time Psychotomimetic Hallucinogen |
| Citations | 30 |
| Key finding | Time underestimation produced by (S)-ketamine could be associated with its antidepressant effects, but was accompanied by severe behavioral disruption. |
Abstract
Time underestimation produced by (S)-ketamine could be associated with its antidepressant effects; however, it was accompanied with severe behavioral disruption. We also hypothesize that behavioral disruption produced by psychedelics objectively reflects their psychotomimetic-like actions.