DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO
Journal of Neurochemistry July 1, 1976 DOI: 10.1111/j.1471-4159.1976.tb01546.x via OpenAlex
Summary
AI-generated from the abstractA single injection of lysergic acid diethylamide (LSD) temporarily breaks apart polysomes, the clusters of ribosomes that assemble proteins, in the brains of young rabbits. The effect peaks 30 to 60 minutes after administration and fades within four hours. Both low (10 μg/kg) and high (100 μg/kg) doses cause this disruption. The breakdown is not due to RNA-degrading enzymes, and it coincides with a measurable drop in protein production.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Young rabbits |
| Dose | 10 or 100 μg/kg body wt |
| Duration | Up to 4 hours |
| Topics | LSD |
| Keywords | Polysome In vivo Dose Pharmacology |
| Citations | 42 |
| Key finding | In vivo administration of LSD transiently disaggregates polysomes and reduces protein synthesis in the brains of young rabbits. |
Abstract
Abstract— Polysomes from three major brain regions of the young rabbit were disaggregated after in vivo administration of d ‐LSD. The effect was transient and demonstrated maximal shift after 30–60 min with a return to normal levels by 4 h. Brain polysome disaggregation was elicited by LSD dosages of either 10 or 100/μg/kg body wt. The polysome shift was not caused by RNase degradation and during maximal disaggregation there was a measurable decrease in protein synthesis.