Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples
Forensic Science International August 1, 1997 DOI: 10.1016/s0379-0738(97)00063-7 via OpenAlex
Summary
AI-generated from the abstractA method to detect and measure LSD in blood serum uses liquid-liquid extraction followed by gas chromatography-mass spectrometry of a trimethylsilyl derivative. Tests on spiked samples recovered 76% of the LSD, with a coefficient of variation of 9.3%. The method is linear across 0.1–10 ng/ml. The work also presents evidence of LSD's sensitivity to light and includes case examples.
Study at a glance
| Characteristics | Method development and validation Peer reviewed |
|---|---|
| Topics | LSD |
| Keywords | Gas chromatography–mass spectrometry Coefficient of variation Extraction chemistry Detection limit |
| Citations | 29 |
| Key finding | A gas chromatography-mass spectrometry method can reliably detect and quantify LSD in serum with 76% recovery and linearity from 0.1 to 10 ng/ml. |
Abstract
A sensitive method for the detection and quantification of lysergic acid diethylamide (LSD) in serum samples is described. After liquid-liquid extraction the trimethylsilyl derivative of LSD is detected by gas chromatography-mass spectrometry. Experiments with spiked samples resulted in a recovery of 76%, the coefficient of variation was 9.3%. Excellent linearity was obtained over the range 0.1-10 ng ml-1. Additionally experiments demonstrating the light sensitivity of LSD are presented together with casuistics.