Comparative subjective effects of seven drugs including lysergic acid diethylamide (LSD-25).
Murray E. Jarvik, Harold A. Abramson, Martin Hirsch
Journal of Abnormal & Social Psychology November 1, 1955 DOI: 10.1037/h0041073 via OpenAlex
Summary
AI-generated from the abstractFive participants were tested nine times under two placebos (tap water) and seven drugs: ergometrine, alcohol, scopolamine, BOL-148, methamphetamine, LAE-32, and LSD-25. They completed a questionnaire about perceptual, physiological, and cognitive states before and 0.5, 2.5, and 4.5 hours after each dose. Differentiation among three lysergic acid derivatives and among alcohol, methamphetamine, and scopolamine was not clear, but the number of responses to the questionnaire under these drugs was clearly greater than under water. LSD-25 produced the most frequent and largest positive responses.
Study at a glance
| Characteristics | Within-subjects experimental Peer reviewed |
|---|---|
| Sample size | 5 |
| Population | Human participants |
| Interventions | ethyl alcohol scopolamine BOL-148 methamphetamine LAE-32 LSD-25 |
| Dose | average effective dose |
| Duration | 4.5 hours after administration |
| Topics | LSD |
| Keywords | Hallucinogen Clinical psychology |
| Citations | 32 |
| Key finding | LSD-25 produced the most frequent and largest positive responses among the seven drugs tested. |
Abstract
Five Ss were tested on nine occasions under two placebos of tap water and under an average effective dose of 7 drugs--ergometerine (Ergonovine), ethyl alcohol, scopolamine (hyroscine), d-1-brom lysergic acid diethylamide (BOL-148), methamphetamine hydrochloride (Methedrine or Pervitin), lysergic acid monoethylamide (LAE-32), and lysergic acid diethylamide (LSD-25) during 9 different experimental sessions . . ... The Ss completed a questionnaire inquiring about their perceptual, physiological and cognitive state before they received the drug or placebo and .5, 2.5 and 4.5 hours after receiving it . . ... Although differentiation between 3 lysergic acid derivatives, Ergonovine, LAE-32, and BOL-148, and between alcohol, methamphetamine, and scopolamine was not clear cut, the number of responses to the questionnaire under these drugs was clearly greater than those given under water . . ... LSD-25 clearly produced the most frequent and the largest positive responses. (PsycINFO Database Record (c) 2006 APA, all rights reserved)