Adverse consequences of lysergic acid diethylamide

Lysergic acid diethylamide (LSD) use is linked to panic reactions, prolonged schizoaffective psychoses, and a post-hallucinogen perceptual disorder that can persist for up to 5 years. Evidence does not support claims that hallucinogens cause genetic disorders. Current data confirm earlier findings that LSD can lead to long-lasting psychopathology in vulnerable individuals. A hypothetical long-term molecular mechanism for these adverse effects is proposed.

Study at a glance

Abstract

Abstract The continued endemic use of hallucinogenic drugs, and of LSD in particular, raises concern regarding their short and long term adverse consequences. The epidemiology of LSD abuse is reviewed suggesting an increase in LSD use among the young as the prevalence rates for other substances continues to fall. Evidence supports the association of LSD use with panic reactions, prolonged schizoaffective psychoses and post–hallucinogen perceptual disorder, the latter being present continually for as long as 5 years. Evidence does not support claims of genetic disorders arising from hallucinogens. In light of the foregoing, current data confirm earlier findings of long lasting psychopathology arising in vulnerable individuals from the use of LSD. A hypothetical long term molecular mechanism of adverse effects is proposed.