Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD
Thomas N. Chase, George R. Breese, Irwin J. Kopin
Science September 22, 1967 DOI: 10.1126/science.157.3795.1461 via OpenAlex
Summary
AI-generated from the abstractSlices of rat brain that had taken up radioactive serotonin, either in a living animal or in a laboratory dish, were washed and then electrically stimulated. This caused a substantial release of the added serotonin, and to a smaller degree its breakdown products. The amount released depended on which brain region was tested, and the release was blocked by lysergic acid diethylamide (LSD).
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rat brain slices |
| Interventions | electrical stimulation lysergic acid diethylamide |
| Topics | LSD Serotonin |
| Keywords | Stimulation In vivo In vitro |
| Citations | 1 |
| Key finding | Electrical stimulation of rat brain slices that had accumulated tritiated serotonin caused release of the amine and its deaminated metabolites, which varied by brain region and was inhibited by lysergic acid diethylamide. |
Abstract
Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.