Characterizing Thalamocortical (Dys)connectivity Following D-Amphetamine, LSD, and MDMA Administration
Mihai Avram, Felix Müller, Helena Rogg, Αλεξάνδρα Κορδά, Christina Andreou, Friederike Holze, Patrick Vizeli, Laura Ley, Matthias E. Liechti, Stefan Borgwardt
Biological Psychiatry Cognitive Neuroscience and Neuroimaging April 29, 2022 DOI: 10.1016/j.bpsc.2022.04.003 via OpenAlex
Summary
AI-generated from the abstractPsychedelics, empathogens, and psychostimulants produce increased connectivity between the thalamus and sensorimotor areas of the brain, a pattern similar to that observed in individuals with psychotic disorders. This suggests a shared neural mechanism across these substances and certain psychiatric conditions, linking altered thalamocortical communication to changes in perception and behavior.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Amphetamine Hallucinogen Psychology Medicine |
| Citations | 43 |
| Key finding | Psychedelics, empathogens, and psychostimulants evoke thalamocortical hyperconnectivity with sensorimotor areas, similar to findings in patients with psychotic disorders. |
Abstract
Psychedelics, empathogens, and psychostimulants evoke thalamocortical hyperconnectivity with sensorimotor areas, akin to findings in patients with psychotic disorders.