Empirical Dimensions of LSD-25 Reaction

Subjective reactions to LSD-25 can be grouped into distinct dimensions based on empirical data, rather than relying solely on clinical concepts. Previous research offered only general descriptions or a priori groupings, and neglected how personality relates to specific reactions. This report presents empirical evidence differentiating major dimensions of the LSD-25 reaction, addressing these gaps by analyzing clusters of reactions, building on earlier work by Salvatore and Hyde and the authors' own prior study.

Study at a glance

Abstract

There has been, thus far, virtually no exploration of anempiricalbasis of the patterning of subjective reactions to lysergic acid diethylamide (LSD-25). Previous studies have been limited to general descriptions of the drug's effects, and the rare attempts to group the various specific effects have been based on a priori clinical concepts1(reviewed elsewhere). Furthermore, the relationships between a given LSD-25 reaction and the personalities of the individuals who manifest that reaction have been neglected. This report presents data bearing on these unexplored areas. The present attempt to differentiate empirically major dimensions of the LSD-25 reaction may be contrasted with previous studies which have presented clinical and, to some extent, systematic summaries of the separate aspects of the drug reaction. Only Salvatore and Hyde3and our own previous report1were concerned with clusters of reactions, and