Simple and Fast Analysis of LSD by Cyclic Voltammetry in Aqueous Medium
Maria Fernanda Muzetti Ribeiro, Érica Naomi Oiye, Juliana Midori Toya Katayama, Antônio José Ipólito, Marcelo Firmino de Oliveira
ECS Transactions October 25, 2017 DOI: 10.1149/08010.1259ecst via OpenAlex
Summary
AI-generated from the abstractA simple, fast, and sensitive voltammetric method using a glassy carbon electrode and an aqueous solution of KClO4 as supporting electrolyte quantifies LSD in seized blotters. The anodic peak at 0.88 V vs. Ag/AgCl is proportional to LSD concentration, with detection and quantification limits of 0.987 and 3.29 µmol L⁻¹, respectively, enabling detection at µg per mL of extraction solution. The method also detects 25H-NBOMe, a compound with psychoactive effects similar to LSD. This less polluting methodology offers a practical tool for forensic analysis of these substances.
Study at a glance
| Characteristics | Method development and validation Peer reviewed |
|---|---|
| Keywords | Context archaeology Detection limit Cyclic voltammetry Aqueous solution Extraction chemistry |
| Citations | 8 |
| Key finding | A voltammetric method using a glassy carbon electrode in aqueous KClO4 can quantify LSD with detection and quantification limits of 0.987 and 3.29 µmol L⁻¹, and can also detect 25H-NBOMe. |
Abstract
The application of electrochemical analysis within the forensic scenario has been widely explored, mainly in the context of the analysis of illicit drugs. In this regard, voltammetric measurements are particularly sensitive and specific. Psychedelic LSD (lysergic acid diethylamide) appears in seized blotters, and its apprehension is constant on a global scale. In this study, we have developed a simple, fast, and sensitive voltammetric method to quantify LSD by using a glassy carbon electrode. The use of an aqueous solution of KClO4 as supporting electrolyte has allowed us to design a less polluting methodology. Concerning the developed method, the anodic peak observed at 0.88 V vs. Ag/AgCl is proportional to the concentration of LSD. The limits of detection and quantification of the method are 0.987 and 3,29 µmol L-1, respectively, which enables detection of LSD at a concentration level of µg per mL of the extraction solution. The same method can also be employed to detect 25H-NBOMe, a compound belonging to the class of NBOMes, which exert practically the same psychoactive effect as LSD.