Severe Neurological Sequelae after a Recreational Dose of LSD
Rachel Aakerøy, Wenche Rødseth Brede, Stian Bergseng Stølen, Hege‐merete Krabseth, Lisbeth Solem Michelsen, Trine Naalsund Andreassen, Tiina Ader, Joachim Frost, Grete Slettom, Ole Martin Steihaug, Lars Slørdal
Journal of Analytical Toxicology October 2, 2020 DOI: 10.1093/jat/bkaa145 via OpenAlex
Summary
AI-generated from the abstractA young man with no prior medical issues had a seizure followed by cardiorespiratory arrest and severe neurological damage after taking a blotter containing 300 µg of LSD. A serum sample taken 3 hours later showed an LSD concentration of 4.0 ng/mL (12.4 nmol/L). No other drugs at significant levels or individual susceptibility factors were found. This suggests that LSD can cause toxic effects in otherwise healthy people.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A young man with unremarkable medical history |
| Dose | 300 µg |
| Topics | LSD |
| Keywords | Cardiorespiratory fitness Adverse effect Recreational use Serum concentration |
| Citations | 9 |
| Key finding | LSD may cause seizure, cardiorespiratory arrest, and severe neurological sequelae in previously healthy individuals. |
Abstract
Abstract A young man with an unremarkable medical history suffered a seizure with subsequent cardiorespiratory arrest and severe neurological sequelae after ingesting a blotter. Analysis of a similar blotter and a serum sample obtained 3 h after the event detected lysergic acid diethylamide (LSD) at an amount of 300 µg in the blotter and at a concentration of 4.0 ng/mL (12.4 nmol/L) in the serum. No other drugs were present in concentrations which may confer significant effects. In addition, no individual traits which would make the patient particularly susceptible to adverse LSD effects have subsequently been identified. This suggests that LSD may confer toxic effects in previously healthy individuals.