Effects of N,N-Dimethyltryptamine (DMT) and 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats
James K. Walters, Michael H. Sheard, Michael Davis
Pharmacology Biochemistry and Behavior July 1, 1978 DOI: 10.1016/0091-3057(78)90016-3 via OpenAlex
Summary
AI-generated from the abstractRats were tested for shock-elicited fighting after receiving various doses of N,N-dimethyltryptamine (0.12 to 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06 to 2.0 mg/kg). Both drugs inhibited fighting at higher doses but had no significant effects at lower doses. These effects differ from those of another indole hallucinogen, d-lysergic acid diethylamide, and are discussed in relation to their impact on the raphe-serotonin system and interactions with other neurotransmitter systems.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | N N-dimethyltryptamine 5-methoxy-N |
| Dose | 0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg for N,N-dimethyltryptamine; 0.06, 0.12, 0.5, 2.0 mg/kg for 5-methoxy-N,N-dimethyltryptamine |
| Topics | LSD Serotonin |
| Keywords | Hallucinogen Pharmacology Tryptamine |
| Citations | 18 |
| Key finding | Both N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine inhibited shock-elicited fighting in rats at higher doses, with no significant effects at lower doses. |
Abstract
Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses. The effects of these drugs on shock elicited fighting, as well as on other behaviors, thus differ from those of another indole hallucinogen, d-lysergic acid diethylamide, and are discussed in relation to their effects on single unit activity of the raphe-serotonin system and their interaction with other neurotransmitter systems.