Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice
Yasmim A. Serra, Thaísa Barros-Santos, Alexia Anjos-Santos, Natali D. Kisaki, Caio Jovita-Farias, João Pereira Leite, Maria Clara E. Santana, João P. S. A. Coimbra, Nailton M. S. de Jesus, Agnieszka Sulima, Paulo César Ribeiro Barbosa, Elena L. A. Malpezzi-Marinho, Kenner C. Rice, Alexandre J. Oliveira-Lima, Laís F. Berro, E.a.v. Marinho
Psychopharmacology March 7, 2022 DOI: 10.1007/s00213-022-06104-w via OpenAlex
Summary
AI-generated from the abstractIn mice undergoing alcohol abstinence, treatment with ayahuasca blocked the return of alcohol self-administration. The effects depended on activation of the 5-HT2A receptor. The findings suggest that ayahuasca and other 5-HT2A receptor agonists could serve as adjunctive pharmacotherapies for alcohol use disorder.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Topics | Ayahuasca |
| Keywords | Self-administration Psychology Pharmacology Receptor |
| Citations | 28 |
| Key finding | Ayahuasca treatment during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT2A receptor activation is critical for those effects. |
Abstract
Treatment with ayahuasca during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT2A receptor activation is critical for those effects to emerge. Our findings support a potential for ayahuasca and other 5-HT2A receptor agonists as adjunctive pharmacotherapies for the treatment of AUD.