The serotonergic hallucinogen 5-MeO-DMT disrupts cortical activity in rodents

A significant connection emerged between serotonin and cognitive processes, revealing that altered brain connectivity may play a role in psychosis. In a sample of 150 individuals, those with schizophrenia exhibited reduced functional connectivity in the prefrontal cortex and precuneus, critical areas for metacognition. This disruption was particularly pronounced when examining the posterior cingulate's interaction with serotonergic receptors. The findings highlight how neuroscience and hallucinogens can inform psychiatry, enhancing our understanding of mental health and the neural dynamics underlying cognition and brain function.

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Abstract

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