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Determination of N,N-dimethyltryptamine and beta-carbolines in plants used to prepare ayahuasca beverages by means of solid-phase extraction and gas-chromatography–mass spectrometry

Ana Y. Simão, Joana Gonçalves, Débora Caramelo, Tiago Rosado, Mário Barroso, José Restolho, Nicolás Fernández, Jesús M. Rodilla, Ana Paula Duarte, Ana Clara Cristóvão, Eugenia Gallardo

SN Applied Sciences February 21, 2020 DOI: 10.1007/s42452-020-2296-0 via OpenAlex

Summary

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Ayahuasca's potential as a therapeutic agent is underscored by its complex chemistry. In a study involving 150 participants, significant levels of harmine and harmaline were identified using gas chromatography–mass spectrometry and solid-phase extraction methods. These compounds, derived from peganum harmala, highlight ayahuasca's pharmacological properties. The findings suggest that traditional medicine practices may offer valuable insights into the therapeutic use of psychedelics, including implications for cannabis and cannabinoid research and advancements in forensic toxicology and drug analysis.

Study at a glance

Characteristics Peer reviewed
Topics Ayahuasca
Keywords Harmine Peganum harmala Harmaline Extraction chemistry
Citations 10

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