A striking 70% of participants reported significant improvements in major depression symptoms after using a traditional medicine derived from the bark of a specific plant. This treatment, rich in tryptamine and indole alkaloids, influences neurotransmitter receptors, highlighting its potential in drug studies. The chemistry behind its stereochemistry reveals how these psychedelics can alter behavior effectively. Additionally, a unique method of administration, such as snuff, enhances absorption and efficacy. With a sample size of 120 individuals, these findings underscore the promising role of botany in mental health treatments.