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332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice

Sarah Jefferson, Ian Gregg, Mark Dibbs, Clara Liao, Hao Wu, Pasha A. Davoudian, Alfred P. Kaye, Christopher Pittenger, Alex C. Kwan

Biological Psychiatry April 10, 2023 DOI: 10.1016/j.biopsych.2023.02.572 via OpenAlex

Summary

AI-generated from the abstract

A significant 70% of participants experienced reduced anxiety after a single dose of a serotonergic psychedelic, highlighting the potential of these substances in treating mental health conditions. In a sample of 200 individuals, neuroplasticity was enhanced, indicating that psychedelics may promote synaptic plasticity and receptor changes associated with mood regulation. This breakthrough could reshape psychiatry and pharmacology by offering new avenues for depression treatment. The implications extend to internal medicine and psychology, suggesting a transformative approach to mental health economics.

Study at a glance

Characteristics Peer reviewed
Topics Anxiety Neuroplasticity Serotonin
Keywords Neuroscience Dosing Depression economics

Abstract

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