In vivometabolism ofα-methyltryptamine in rats: Identification of urinary metabolites
Tatsuyuki Kanamori, Kenji Kuwayama, Kenji Tsujikawa, Hajime Miyaguchi, Yuko Iwata, Hiroyuki Inoue
Xenobiotica November 3, 2008 DOI: 10.1080/00498250802491654 via OpenAlex
Summary
AI-generated from the abstractAlpha-methyltryptamine (AMT), a psychoactive tryptamine analogue, is metabolized in rats into at least four distinct compounds. After oral administration of 10 mg/kg to male Wistar rats, urine collected over 24 hours was enzymatically hydrolyzed, extracted, and analyzed by gas chromatography/mass spectrometry. The detected metabolites were 2-oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT, and 1'-hydroxy-AMT. These findings identify specific metabolic pathways for AMT, which may inform understanding of its pharmacological effects and duration of action.
Study at a glance
| Characteristics | In vivo animal study Peer reviewed |
|---|---|
| Population | Male Wistar rats |
| Keywords | Urine Tryptamine In vivo Metabolism Metabolite |
| Citations | 11 |
| Key finding | AMT is metabolized in rats to 2-oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT, and 1'-hydroxy-AMT. |
Abstract
1. The in vivo metabolism of alpha-methyltryptamine (AMT), a psychoactive tryptamine analogue, was studied in rats. 2. Male Wistar rats were administered 10 mg kg(-1) AMT orally and 24-h urine fractions were collected. After enzymatic hydrolysis of the urine sample, the metabolites were extracted by liquid-liquid extraction and analysed by gas chromatography/mass spectrometry (GC/MS). 3. 2-Oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT and 1'-hydroxy-AMT were detected as metabolites of AMT.