Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Boris D. Heifets, Juliana S. Salgado, Madison Taylor, Paul Hoerbelt, Daniel F. Cardozo Pinto, Elizabeth E. Steinberg, Jessica J. Walsh, Ji Ying Sze, Robert C. Malenka
Science Translational Medicine December 11, 2019 DOI: 10.1126/scitranslmed.aaw6435 via OpenAlex
Summary
AI-generated from the abstractMDMA's prosocial effects can be separated from its addictive properties by using fenfluramine, a selective serotonin-releasing compound. This finding reveals a conserved neuronal pathway that could be targeted to develop new therapeutics with limited abuse liability, offering a potential strategy for creating safer treatments that promote social connection without the risks of addiction.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Prosocial behavior Neuroscience Psychology Pharmacology |
| Citations | 119 |
| Key finding | MDMA's prosocial effects can be dissociated from its addictive properties via a conserved neuronal pathway, suggesting a route to develop therapeutics with limited abuse liability. |
Abstract
-fenfluramine, a selective serotonin-releasing compound. By dissociating the mechanisms of MDMA's prosocial effects from its addictive properties, we provide evidence for a conserved neuronal pathway, which can be leveraged to develop novel therapeutics with limited abuse liability.