Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model*
Jon E. Sprague, Petra Moze, David Caden, Daniel E. Rusyniak, Courtney Holmes, David S. Goldstein, Edward Mills
Critical Care Medicine June 1, 2005 DOI: 10.1097/01.ccm.0000165969.29002.70 via OpenAlex
Summary
AI-generated from the abstractMDMA (ecstasy) can cause dangerously high body temperature (hyperthermia). New evidence suggests that alpha1 and beta3-adrenergic receptors play a role in this effect. The drug carvedilol, which blocks these receptors, may be a promising candidate for treating psychostimulant-induced hyperthermia and its complications, such as rhabdomyolysis. Further research into such therapies is warranted.
Study at a glance
| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Hyperthermia Carvedilol Pharmacology |
| Citations | 75 |
| Key finding | Alpha1 and beta3-adrenergic receptors may contribute to MDMA-induced hyperthermia, and drugs targeting these receptors, such as carvedilol, warrant further investigation as treatments. |
Abstract
These data show that alpha1 and beta3-adrenergic receptors may contribute to the mediation of MDMA-induced hyperthermia and that drugs targeting these receptors, such as carvedilol, warrant further investigation as novel therapies for the treatment of psychostimulant-induced hyperthermia and its sequelae.