Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats
Anna M.s. Kindlundh-Högberg, Anna Blomqvist, Rana Malki, Helgi B. Schiöth
BMC Neuroscience April 17, 2008 DOI: 10.1186/1471-2202-9-39 via OpenAlex
Summary
AI-generated from the abstractRepeated intermittent administration of MDMA alters gene-transcript expression of glutamatergic NMDA and AMPA receptor subunits, metabotropic receptors, and transporters in brain regions that regulate reward-related associative learning, cognition, memory, and neuro-endocrine functions.
Study at a glance
| Characteristics | Preclinical study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | MDMA |
| Topics | MDMA |
| Keywords | Metabotropic glutamate receptor Ampa receptor Nmda receptor Metabotropic receptor Glutamatergic |
| Citations | 40 |
| Key finding | Repeated intermittent MDMA administration induces neuroadaptive changes in gene-transcript expressions of glutamatergic NMDA and AMPA receptor subunits, metabotropic receptors and transporters in brain regions regulating reward-related associative learning, cognition, memory, and neuro-endocrine functions. |
Abstract
Repeated intermittent MDMA administration induces neuroadaptive changes in gene-transcript expressions of glutamatergic NMDA and AMPA receptor subunits, metabotropic receptors and transporters in regions of the brain regulating reward-related associative learning, cognition, and memory and neuro-endocrine functions.