The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity
Robin Carhart‐Harris, Kevin Murphy, Robert Leech, David Erritzøe, Matthew B. Wall, B. Ferguson, Luke T. J. Williams, Leor Roseman, Stefan Brugger, Ineke de Meer, Mark Tanner, Robin J. Tyacke, Kim Wolff, Arjun Sethi, Michael Bloomfield, Tom A. Williams, Mark Bolstridge, Lorna Stewart, Celia J. A. Morgan, Rexford D. Newbould, Amanda Feilding, Hv Curran, David Nutt
Biological Psychiatry January 10, 2014 DOI: 10.1016/j.biopsych.2013.12.015 via OpenAlex
Summary
AI-generated from the abstractThe medial temporal lobes (MTLs) are specifically involved in how MDMA works in the brain, though more research is needed to understand how the drug's characteristic subjective effects emerge from its modulation of spontaneous brain activity.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Euphoriant Cerebral blood flow Psychology Amygdala |
| Citations | 182 |
| Key finding | The medial temporal lobes appear to be specifically implicated in the mechanism of action of MDMA. |
Abstract
The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug's characteristic subjective effects arise from its modulation of spontaneous brain activity.