Lasting Neuropsychiatric Sequelae of (??)Methylenedioxymethamphetamine (???Ecstasy???) in Recreational Users
Una D. Mccann, George A. Ricaurte, Domenic A. Ciraulo
Journal of Clinical Psychopharmacology October 1, 1991 DOI: 10.1097/00004714-199110000-00005 via OpenAlex
Summary
AI-generated from the abstractTwo people who took large doses of MDMA, a recreational amphetamine analog, developed long-lasting neuropsychiatric syndromes. These cases suggest that MDMA, which is known to damage serotonin neurons in animals, may also cause harmful effects in humans. The evidence indicates that ingesting large amounts of MDMA can lead to lasting adverse functional consequences in vulnerable individuals.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 2 |
| Population | Persons who ingested large doses of MDMA |
| Intervention | MDMA |
| Dose | large doses |
| Topics | LSD MDMA Serotonin |
| Keywords | Hallucinogen Ingestion Serotonin syndrome |
| Citations | 137 |
| Key finding | Ingestion of large doses of MDMA can produce lasting adverse neuropsychiatric effects in vulnerable persons. |
Abstract
Two persons are described who demonstrated prolonged neuropsychiatric syndromes after the ingestion of large doses of (+-)-3,4-methylenedioxymethamphetamine (MDMA), a recreationally used amphetamine analog. These cases suggest that MDMA, known to be neurotoxic to serotonin neurons in several experimental animals, may also produce untoward effects in humans. In addition, they provide evidence that ingestion of large doses of MDMA can produce lasting adverse functional consequences in vulnerable persons.