Effect of mescaline on single cortical neurones
C. M. Bradshaw, M.h.t. Roberts, E. Szabadi
British Journal of Pharmacology December 1, 1971 DOI: 10.1111/j.1476-5381.1971.tb07225.x via OpenAlex
Summary
AI-generated from the abstractMescaline applied directly to single neurons in the cerebral cortex produces excitatory or depressant effects similar to those of noradrenaline and serotonin. The direction of the response to mescaline usually matches that of noradrenaline, but the correlation with serotonin is less consistent. The beta-adrenoceptor blocker MJ-1999 and the serotonin antagonist methysergide both block mescaline's effects, suggesting mescaline acts through multiple receptor mechanisms.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Single cortical neurons (in vivo, likely animal) |
| Interventions | Mescaline Noradrenaline 5-Hydroxytryptamine MJ-1999 Methysergide |
| Topics | Mescaline |
| Keywords | Methysergide Chemistry Pharmacology Antagonist |
| Citations | 16 |
| Key finding | Mescaline excites or depresses cortical neurons similarly to noradrenaline, and both MJ-1999 and methysergide antagonize these responses. |
Abstract
The effects of mescaline upon single cortical neurones were studied, using the microiontophoretic technique. Mescaline elicited excitatory and depressant responses similar to those evoked by noradrenaline (NA) and 5-hydroxytryptamine (5-HI). The responses to NA and mescaline were usually in the same direction, the neurone being either excited by both drugs or depressed by both drugs. The correlation between the effects of mescaline and 5-HT, however, was less consistent. The beta-adrenoceptor blocking agent MJ-1999 and the 5-HT antagonist methysergide were both effective in antagonizing mescaline responses.